The hydrogen chloride oxidation process that Sumitomo Chemical Co., Ltd. has developed is an environmentally friendly chlorine production process. In this article we propose a plan for a sustainable future from the perspective of halogen recycling, in which by-product hydrogen halides are converted into halogens, and also introduce the features of the Sumitomo Chemical's process.
(by Masayuki IKEGUCHI, Kohei SEKI, Yasuhiko MORI)

Oxazosulfyl is a novel insecticide originally discovered and developed by Sumitomo Chemical Co., Ltd. It belongs to a new chemical class, the "Sulfyl" group, structurally characterized by its ethylsulfonyl moiety. In nursery box application, it exhibits excellent control against a broad range of major rice insect pests, including Hemiptera, Coleoptera, Lepidoptera and Orthoptera. Field studies in in-house and contracted rice paddy fields demonstrate that Oxazosulfyl is highly effective against local populations of planthoppers and rice leaf beetles that have developed high resistance to existing insecticides. Oxazosulfyl was registered as "ALLES® granule", which contains 2.0%(w/w) Oxazosulfyl, in April 2021.
(by Emiko SAKAMOTO, Shinya NISHIMURA, Tatsuya SUZUKI, Mai ITO, Yoshihiko NOKURA, Mitsuhiro SASAKAWA, Daisuke SASAYAMA, Ryo IHARA, Yuko HANDA)

DSP-1181 is a novel compound which was discovered by Sumitomo Dainippon Pharma Co., Ltd. using AI (Artificial Intelligence) technology of Exscientia Ltd. It has garnered attention for completing drug discovery research in less than 12 months, compared to the industry average of four and a half years. DSP-1181 has been developed as an orally active agent for OCD (Obsessive Compulsive Disorder), and its Phase 1 study was initiated in Japan in 2020. Here, we introduce an innovative approach to the drug discovery of DSP-1181 utilizing AI, optogenetic technology, and translational biomarkers.
(by Hideaki IMAI, Hidefumi YOSHINAGA, Tatsuya ISHIKAWA)

The following two numerical methods were developed in order to provide several computational methods that overcome the computing load issues of three-dimensional simulations based on fluid dynamics:
(1) a method incorporating bent channel shapes in structured grids (improved cut-cell method)
(2) a stable method for solving flows using a high aspect ratio grid
In the first method, we attempted to improve the cut-cell method for boundary layer computation near industrially important walls. The improvement demonstrated that the cavity flow and the flow around obstacles can be calculated accurately. In the second method, we confirmed that the same flow field can be calculated even when the aspect ratio of the computational grid is increased from 1 to 100, and we simulated the temperature and flow of a large-scale ocean area.
(by Naoki SHIMADA)

The Classification, Labelling and Packaging (CLP) Regulation published in 2008, which replaced the classification, packaging and labelling of Dangerous Substances Directive (DSD) published in 1967, incorporated the internationally agreed Globally Harmonised System of Classification and Labelling of Chemicals (GHS) into Community law and did not only place all existing EU harmonised classifications listed under the DSD in a table in an annex to the CLP Regulation, but also converted all existing classifications into GHS classifications using the GHS criteria and placed them in another table in the annex. Under the CLP Regulation, a chemical Active Substance (AS) of a Plant Protection Product (PPP) or Biocidal Product (BP) is normally subjected to Harmonised Classifications and Labelling (CLH). In this article, the provisions introduced by the CLP Regulation, the changes on the procedures for setting/revising CLH, increased importance of CLH in the evaluation processes for active substances in PPPs and BPs, etc. are summarised.
(by Hiroko HARADA, Mio TATSU, Mika OTA)